Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R01 Clinical Trial Optional) | PAR 19 360

Opportunity Information: Apply for PAR 19 360

This NIH grant opportunity, titled "Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R01 Clinical Trial Optional)" (Funding Opportunity Number PAR-19-360), supports research that digs into a very practical problem in cancer prevention and immunization: a clinician recommending the HPV vaccine is one of the strongest drivers of adolescent vaccination, but that recommendation does not always happen, and even when it does, it does not always translate into actual vaccine uptake. The focus of the announcement is the healthcare delivery system itself, looking at how the way care is organized, delivered, and experienced can either strengthen or weaken the impact of a provider's recommendation on whether adolescents initiate and complete the HPV vaccine series. The overall goal is to produce evidence that can help close the gap between recommendation and real-world vaccination, ultimately reducing HPV-related cancers.

The FOA emphasizes that HPV vaccine uptake is not determined by a single factor; it is shaped by interacting characteristics across three main domains: the provider, the parent/patient, and the clinical setting. Provider-related influences can include communication style, strength and clarity of the recommendation, comfort addressing vaccine concerns, time pressures, competing priorities during visits, training, implicit bias, and how clinicians interpret guidelines. Parent and patient factors can include beliefs about vaccines, cancer risk perceptions, trust in healthcare, health literacy, prior experiences, cultural norms, concerns about safety or sexual activity misconceptions, and practical barriers such as transportation or scheduling. Clinical setting factors can include clinic workflow, reminder and recall systems, use of standing orders, electronic health record prompts, team-based care models, availability of same-day vaccination, after-hours access, billing and reimbursement processes, and whether preventive care is consistently integrated into adolescent visits. The NIH is looking for research that connects these system and contextual factors directly to whether provider recommendations occur and whether they successfully lead to vaccination.

Because the problem sits at the intersection of behavior, prevention, and healthcare operations, the announcement signals a need for multidisciplinary research teams. It highlights expertise areas such as cancer prevention, adult and child or adolescent behavior, immunization promotion, and healthcare delivery or health services research. In practice, that points to studies that can combine clinical insights with implementation science, behavioral science, communication research, and health systems engineering, and that can evaluate interventions or strategies in real clinical environments. The activity mechanism is the R01 (research project grant), and clinical trials are optional, meaning applicants may propose either observational, mixed-methods, or intervention studies, including trials, as long as the design fits the research questions and the NIH definition of a clinical trial if applicable.

Eligibility is broad across public, private, nonprofit, and for-profit entities in the United States. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other eligible entities. The FOA also explicitly calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, Asian American Native American Pacific Islander Serving Institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments other than federally recognized entities, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-U.S. organizations and non-U.S. institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as NIH defines them) are not allowed under this announcement.

Administratively, this is a discretionary grant opportunity from the National Institutes of Health. The funding activity category is listed under education and health, and the associated CFDA numbers are 93.393 and 93.395. The FOA record shows a creation date of August 29, 2019, and an original closing date of September 7, 2022, indicating it was part of a defined application window or cycle during that period. While the provided record does not specify an award ceiling or expected number of awards, the intent is clearly to fund rigorous R01-level research that can explain and improve the pathway from clinician recommendation to adolescent HPV vaccination, with attention to real-world healthcare delivery conditions and the multiple human factors that influence vaccination decisions.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.395.
• This funding opportunity was created on 2019-08-29.
• Applicants must submit their applications by 2022-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 360

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: