Opportunity Information: Apply for W81XWH 20 LCRP IITRA
The DoD Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA) is a FY20 funding opportunity from the Department of Defense (administered through the U.S. Army Medical Research Acquisition Activity, USAMRAA) aimed at pushing lung cancer research ideas beyond discovery and into practical clinical use. The award is designed specifically for translational research, meaning projects that deliberately connect basic science work (such as lab-based biology, molecular findings, or animal model experiments) with real clinical observations (such as patient outcomes, clinical trial insights, or patterns seen in populations). A central theme is that successful translation is not supposed to be a one-direction path from bench to bedside; instead, proposals are expected to show a two-way, iterative exchange where clinical realities inform the lab strategy and lab discoveries, in turn, shape clinical approaches.
This mechanism is meant to support a wide range of translational studies that can credibly move a lung cancer concept closer to patient impact. Examples include taking results from in vitro experiments or animal studies and advancing them into studies that use human biospecimens, patient-derived materials, or well-defined human cohorts. It also includes late-stage preclinical efforts that position a therapy, diagnostic, or intervention for entry into clinical testing, such as the kind of work needed to prepare for a clinical trial or support an Investigational New Drug (IND) submission. In addition, the program supports correlative and companion studies tied to clinical trials, whether those trials are currently open, ongoing, or already completed, and it encourages projects that develop or refine clinical trial endpoints, such as biomarkers or other measurable indicators that can help interpret whether an intervention is working and why.
A key requirement is that applicants must include preliminary data that is clearly relevant to lung cancer and that demonstrates feasibility for the proposed hypothesis and research approach. In other words, this award is not intended for purely speculative early concepts; it is targeted at ideas that already have enough supporting evidence to justify a focused push toward clinical application. The opportunity is listed as discretionary and uses grant and cooperative agreement instruments, falls under the Science and Technology/Research and Development activity category, and is associated with CFDA number 12.420. Eligibility is described as unrestricted (open to any entity type) unless further limitations are specified elsewhere in the full announcement. For FY20, the expected number of awards was three, and the award ceiling is listed as 0 in the source text (which often indicates that the maximum is not specified in the summary field and must be confirmed in the full program announcement). The opportunity number is W81XWH 20 LCRP IITRA, it was created March 12, 2020, and the original closing date was July 29, 2020.Apply for W81XWH 20 LCRP IITRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lung Cancer, Investigator-Initiated Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 12, 2020.
- Applicants must submit their applications by Jul 29, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs): DoD Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA) - FY20
What is the LCRP Investigator-Initiated Translational Research Award (IITRA)?
The LCRP Investigator-Initiated Translational Research Award (IITRA) is a FY20 Department of Defense funding opportunity intended to push lung cancer research beyond discovery and toward practical clinical use. It specifically targets translational research that connects laboratory and preclinical work with clinical observations and patient-focused application.
Which agency is offering and administering this opportunity?
The funding opportunity is from the Department of Defense (DoD) and is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the main goal of this award?
The main goal is to support lung cancer translational research that can credibly move a concept closer to patient impact, including activities that help bridge early findings into clinically relevant studies or enable entry into clinical testing.
What does "translational research" mean in this opportunity?
In this program, translational research means projects that deliberately connect basic science (for example, molecular findings, lab biology, in vitro experiments, or animal model work) with clinical observations (for example, patient outcomes, clinical trial insights, or population patterns). Proposals are expected to show how the clinical setting informs lab strategy and how lab discoveries inform clinical approaches.
Does the program expect translation to be only "bench to bedside"?
No. A central theme is that translation should be a two-way, iterative exchange. Clinical realities should shape the laboratory approach, and laboratory discoveries should help shape clinical strategies.
What kinds of studies does the IITRA support?
The award supports a broad range of translational studies that can move lung cancer concepts toward clinical impact. Examples listed include: advancing in vitro or animal model results into human biospecimen or patient-derived studies; late-stage preclinical work that positions a therapy, diagnostic, or intervention for clinical testing; correlative and companion studies tied to clinical trials; and development or refinement of clinical trial endpoints such as biomarkers.
Can projects transition from animal or in vitro work into human-focused studies under this award?
Yes. One example described is taking results from in vitro experiments or animal studies and advancing them into studies that use human biospecimens, patient-derived materials, or well-defined human cohorts.
Does the opportunity support late-stage preclinical work aimed at clinical testing?
Yes. The program includes late-stage preclinical efforts that position a therapy, diagnostic, or intervention for entry into clinical testing, including work needed to prepare for a clinical trial or support an Investigational New Drug (IND) submission.
Are correlative or companion studies for clinical trials allowed?
Yes. The program supports correlative and companion studies tied to clinical trials, including trials that are open, ongoing, or already completed.
Does the program encourage biomarker or endpoint development?
Yes. It encourages projects that develop or refine clinical trial endpoints, including biomarkers or other measurable indicators that help interpret whether an intervention is working and why.
Is preliminary data required?
Yes. Applicants must include preliminary data that is clearly relevant to lung cancer and that demonstrates feasibility for the proposed hypothesis and research approach.
Is this award appropriate for early, highly speculative ideas without supporting evidence?
No. The opportunity is described as not intended for purely speculative early concepts. It targets ideas that already have enough supporting evidence to justify a focused push toward clinical application.
What is the activity category associated with this opportunity?
The opportunity falls under the Science and Technology/Research and Development activity category.
What funding instruments are used for this opportunity?
The listing indicates that it uses grant and cooperative agreement instruments.
What is the CFDA number associated with this program?
The associated CFDA number is 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any entity type) unless additional limitations are specified elsewhere in the full announcement.
How many awards were expected to be made in FY20?
For FY20, the expected number of awards was three.
What is the maximum funding amount (award ceiling)?
The award ceiling is listed as 0 in the provided source summary. This often indicates the maximum is not specified in the summary field and would need to be confirmed in the full program announcement.
What is the opportunity number for this award?
The opportunity number is W81XWH 20 LCRP IITRA.
When was this opportunity created?
The opportunity was created on March 12, 2020.
What was the closing date for applications?
The original closing date listed is July 29, 2020.
Is this opportunity discretionary?
Yes. The opportunity is listed as discretionary.
What is the overall emphasis of the IITRA mechanism?
The emphasis is on credible translation of lung cancer research toward clinical utility, supported by lung cancer-relevant preliminary data, and shaped by an iterative exchange between laboratory research and clinical realities.
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