Opportunity Information: Apply for W81XWH 20 LCRP IITRA

The DoD Lung Cancer Research Program (LCRP) Investigator-Initiated Translational Research Award (IITRA) is a FY20 funding opportunity from the Department of Defense (administered through the U.S. Army Medical Research Acquisition Activity, USAMRAA) aimed at pushing lung cancer research ideas beyond discovery and into practical clinical use. The award is designed specifically for translational research, meaning projects that deliberately connect basic science work (such as lab-based biology, molecular findings, or animal model experiments) with real clinical observations (such as patient outcomes, clinical trial insights, or patterns seen in populations). A central theme is that successful translation is not supposed to be a one-direction path from bench to bedside; instead, proposals are expected to show a two-way, iterative exchange where clinical realities inform the lab strategy and lab discoveries, in turn, shape clinical approaches.

This mechanism is meant to support a wide range of translational studies that can credibly move a lung cancer concept closer to patient impact. Examples include taking results from in vitro experiments or animal studies and advancing them into studies that use human biospecimens, patient-derived materials, or well-defined human cohorts. It also includes late-stage preclinical efforts that position a therapy, diagnostic, or intervention for entry into clinical testing, such as the kind of work needed to prepare for a clinical trial or support an Investigational New Drug (IND) submission. In addition, the program supports correlative and companion studies tied to clinical trials, whether those trials are currently open, ongoing, or already completed, and it encourages projects that develop or refine clinical trial endpoints, such as biomarkers or other measurable indicators that can help interpret whether an intervention is working and why.

A key requirement is that applicants must include preliminary data that is clearly relevant to lung cancer and that demonstrates feasibility for the proposed hypothesis and research approach. In other words, this award is not intended for purely speculative early concepts; it is targeted at ideas that already have enough supporting evidence to justify a focused push toward clinical application. The opportunity is listed as discretionary and uses grant and cooperative agreement instruments, falls under the Science and Technology/Research and Development activity category, and is associated with CFDA number 12.420. Eligibility is described as unrestricted (open to any entity type) unless further limitations are specified elsewhere in the full announcement. For FY20, the expected number of awards was three, and the award ceiling is listed as 0 in the source text (which often indicates that the maximum is not specified in the summary field and must be confirmed in the full program announcement). The opportunity number is W81XWH 20 LCRP IITRA, it was created March 12, 2020, and the original closing date was July 29, 2020.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lung Cancer, Investigator-Initiated Translational Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Mar 12, 2020.
  • Applicants must submit their applications by Jul 29, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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